Warning (512): _cake_core_ cache was unable to write 'cake_dev_eng' to File cache [CORE/Cake/Cache/Cache.php, line 323]
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                ),
                E_USER_WARNING
            );
$key = 'cake_dev_eng'
$value = array(
	'LC_MESSAGES' => array()
)
$config = '_cake_core_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/persistent/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
I18n::translate() - CORE/Cake/I18n/I18n.php, line 237
__d - CORE/Cake/basics.php, line 617
Cache::write() - CORE/Cake/Cache/Cache.php, line 321
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

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                ),
                E_USER_WARNING
            );
$key = 'default_citloci_list'
$value = null
$config = '_cake_model_'
$settings = array(
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	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 219
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

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                ),
                E_USER_WARNING
            );
$key = 'default_citloci_list'
$value = array(
	(int) 0 => 'conserved_region_elements',
	(int) 1 => 'conserved_regions',
	(int) 2 => 'diffexp',
	(int) 3 => 'experiment',
	(int) 4 => 'expressed_transcripts',
	(int) 5 => 'external_accessions',
	(int) 6 => 'genes',
	(int) 7 => 'go_annotations',
	(int) 8 => 'homologues',
	(int) 9 => 'maptranscripttoregion',
	(int) 10 => 'organism',
	(int) 11 => 'sample',
	(int) 12 => 'study',
	(int) 13 => 'synonyms',
	(int) 14 => 'transcripts'
)
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::listSources() - CORE/Cake/Model/Datasource/DataSource.php, line 110
Mysql::listSources() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 236
Model::setSource() - CORE/Cake/Model/Model.php, line 1142
Model::getDataSource() - CORE/Cake/Model/Model.php, line 3551
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

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                ),
                E_USER_WARNING
            );
$key = 'default_citloci_genes'
$value = null
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
DataSource::describe() - CORE/Cake/Model/Datasource/DataSource.php, line 135
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 332
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165

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                ),
                E_USER_WARNING
            );
$key = 'default_citloci_genes'
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		'default' => null,
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		'null' => false,
		'default' => null,
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		'collate' => 'latin1_swedish_ci',
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)
$config = '_cake_model_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/models/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DataSource::_cacheDescription() - CORE/Cake/Model/Datasource/DataSource.php, line 310
Mysql::describe() - CORE/Cake/Model/Datasource/Database/Mysql.php, line 372
Model::schema() - CORE/Cake/Model/Model.php, line 1372
DboSource::fields() - CORE/Cake/Model/Datasource/DboSource.php, line 2491
DboSource::read() - CORE/Cake/Model/Datasource/DboSource.php, line 1054
Model::_readDataSource() - CORE/Cake/Model/Model.php, line 2947
Model::find() - CORE/Cake/Model/Model.php, line 2919
DboSource::query() - CORE/Cake/Model/Datasource/DboSource.php, line 597
Model::__call() - CORE/Cake/Model/Model.php, line 808
Gene::findByid() - APP/Controller/GeneController.php, line 302
GeneController::show() - APP/Controller/GeneController.php, line 302
ReflectionMethod::invokeArgs() - [internal], line ??
Controller::invokeAction() - CORE/Cake/Controller/Controller.php, line 490
Dispatcher::_invoke() - CORE/Cake/Routing/Dispatcher.php, line 191
Dispatcher::dispatch() - CORE/Cake/Routing/Dispatcher.php, line 165
[main] - APP/webroot/index.php, line 108

C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

• HOME
• REGIONS
• GENES
• TRANSCRIPTS
• HELP
• CONTACT

Gene Info
Description:	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synth
Gene Accession	Gene Name	Tax ID	Strand	Position	Gene Biotype
ENSMUSG00000021048	Mthfd1	10090	+	12:76255232-76319820	protein_coding
	Transcript Accession		Transcript Name	Position	Transcript Biotype
	ENSMUST00000021443		Mthfd1-201	76255232-76319820	protein_coding

Expression Patterns Heat Map Numeric Values Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis ENSMUST00000021443 11.179±3.37 7.826±1.53 13.604±0.69 12.864±3.76 6.575±0.75 10.057±0.77 6.728±0.46 61.052±2.12 51.998±13.35 18.082±2.48 9.788±0.57 14.890±5.53 19.588±9.38 1.885±0.20

Conserved Regions
Gene is not located within a conserved region.

Gene Ontology
GO ID	Evidence Type	GO Description
GO:0000105	IEA	histidine biosynthetic process
GO:0004329	IBA	formate-tetrahydrofolate ligase activity
GO:0004477	IBA	methenyltetrahydrofolate cyclohydrolase activity
GO:0004488	IBA	methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524	IEA	ATP binding
GO:0005739	IDA	mitochondrion
GO:0005829	IBA	cytosol
GO:0006164	IEA	purine nucleotide biosynthetic process
GO:0006730	IBA	one-carbon metabolic process
GO:0009086	IEA	methionine biosynthetic process
GO:0009396	IEA	folic acid-containing compound biosynthetic process
GO:0016020	IEA	membrane
GO:0035999	IEA	tetrahydrofolate interconversion
GO:0055114	IEA	oxidation-reduction process
GO:0070062	IEA	extracellular vesicular exosome

Homologs
ENSEMBL Accession	Gene Name	Description	Biotype	Species
ENSDARG00000018266	mthfd1a	MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1a	protein_coding	Danio_rerio
ENSDARG00000040492	mthfd1b	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b	protein_coding	Danio_rerio
ENSG00000100714	MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate syn	protein_coding	Homo_sapiens

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                ),
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	'ErrorHandler' => '/var/www/c-it-loci/lib/Cake/Error/ErrorHandler.php',
	'CakePlugin' => '/var/www/c-it-loci/lib/Cake/Core/CakePlugin.php',
	'CakeLog' => '/var/www/c-it-loci/lib/Cake/Log/CakeLog.php',
	'LogEngineCollection' => '/var/www/c-it-loci/lib/Cake/Log/LogEngineCollection.php',
	'ObjectCollection' => '/var/www/c-it-loci/lib/Cake/Utility/ObjectCollection.php',
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	'CakeLogInterface' => '/var/www/c-it-loci/lib/Cake/Log/CakeLogInterface.php',
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$config = '_cake_core_'
$settings = array(
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Cache::write() - CORE/Cake/Cache/Cache.php, line 323
App::shutdown() - CORE/Cake/Core/App.php, line 899
[main] - [internal], line ??

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                ),
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			(int) 10 => '`Gene`.`gene_biotype`',
			(int) 11 => '`Gene`.`annotation_version`',
			(int) 12 => '`Gene`.`gene_description`'
		)
	)
)
$config = '_cake_core_'
$settings = array(
	'prefix' => '*****',
	'engine' => 'File',
	'path' => '/var/www/c-it-loci/app/tmp/cache/persistent/',
	'serialize' => true,
	'duration' => (int) 10,
	'lock' => true,
	'isWindows' => false,
	'mask' => (int) 436,
	'probability' => (int) 100,
	'groups' => array()
)
$success = false
Cache::write() - CORE/Cake/Cache/Cache.php, line 323
DboSource::__destruct() - CORE/Cake/Model/Datasource/DboSource.php, line 3539
[main] - [internal], line ??