C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate syn
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100714 MTHFD1 9606 + 14:64388031-64463457 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000216605 MTHFD1-019 64388350-64460004 protein_coding
  ENST00000545908 MTHFD1-002 64388031-64463457 protein_coding
  ENST00000553391 MTHFD1-011 64424215-64427473 processed_transcript
  ENST00000553405 MTHFD1-008 64441248-64453807 retained_intron
  ENST00000554057 MTHFD1-010 64419203-64426192 processed_transcript
  ENST00000554353 MTHFD1-013 64457997-64460003 retained_intron
  ENST00000554677 MTHFD1-009 64431828-64441812 retained_intron
  ENST00000554739 MTHFD1-015 64388308-64415429 protein_coding
  ENST00000554768 MTHFD1-005 64388308-64415435 protein_coding
  ENST00000555252 MTHFD1-003 64388311-64440447 retained_intron
  ENST00000555709 MTHFD1-001 64388240-64418024 protein_coding
  ENST00000555858 MTHFD1-007 64435567-64439376 retained_intron
  ENST00000556284 MTHFD1-012 64449501-64459982 processed_transcript
  ENST00000556771 MTHFD1-018 64440221-64445138 retained_intron
  ENST00000557370 MTHFD1-014 64449611-64455173 protein_coding
  ENST00000557539 MTHFD1-006 64388727-64415710 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000216605ENST00000556284
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000216605 36.191±0.00 10.518±0.00 13.225±0.00 10.053±3.94 25.733±13.92 10.272±0.90 8.783±4.90 28.679±10.18 29.635±23.54 7.774±1.26 29.641±22.77 11.205±2.45 10.092±1.28 6.359±2.87
ENST00000556284 N/A N/A N/A N/A N/A N/A N/A N/A 52.141±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000105 IEA histidine biosynthetic process
GO:0003824 IEA catalytic activity
GO:0004329 IBA:IEA formate-tetrahydrofolate ligase activity
GO:0004477 IBA methenyltetrahydrofolate cyclohydrolase activity
GO:0004486 TAS methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
GO:0004488 IEA:IBA methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 IEA ATP binding
GO:0005739 IEA mitochondrion
GO:0005829 IBA cytosol
GO:0006164 IEA purine nucleotide biosynthetic process
GO:0006730 IBA one-carbon metabolic process
GO:0006766 TAS vitamin metabolic process
GO:0006767 TAS water-soluble vitamin metabolic process
GO:0009086 IEA methionine biosynthetic process
GO:0009396 IEA folic acid-containing compound biosynthetic process
GO:0016020 IDA membrane
GO:0035999 IEA tetrahydrofolate interconversion
GO:0044281 TAS small molecule metabolic process
GO:0046655 TAS folic acid metabolic process
GO:0055114 IEA oxidation-reduction process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018266 mthfd1a MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1a protein_coding Danio_rerio
ENSDARG00000040492 mthfd1b methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b protein_coding Danio_rerio
ENSMUSG00000021048 Mthfd1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synth protein_coding Mus_musculus

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