C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: SHANK-associated RH domain interactor
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000398712 SHARPIN-001 ENSG00000179526 9606 - 8:144098637-144104190 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastHeartKidneyLiverLungOvaryPlacentaTestisENST00000398712
Transcript ID Adipose Adrenal Brain Breast Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000398712 35.112±0.00 19.758±0.00 4.936±0.00 26.866±0.00 18.785±0.00 13.577±11.00 13.350±0.00 29.564±0.00 34.856±2.59 30.380±2.95 46.723±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007SS CIL_0007SS_0001 VISTA 8:143880613-144482307
CIL_00026W CIL_00026W_0001 CGP 8:144095027-144108124
CIL_0006Y3 CIL_0006Y3_0002 CGP 8:144098633-144108124

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005829 IDA cytosol
GO:0007005 IEA mitochondrion organization
GO:0007420 IEA brain development
GO:0008270 IEA zinc ion binding
GO:0008544 IEA epidermis development
GO:0010803 IDA regulation of tumor necrosis factor-mediated signaling pathway
GO:0014069 IEA postsynaptic density
GO:0030054 IEA cell junction
GO:0030262 IEA apoptotic nuclear changes
GO:0030425 IEA dendrite
GO:0031424 IEA keratinization
GO:0031593 IDA polyubiquitin binding
GO:0032403 IEA protein complex binding
GO:0042802 IEA identical protein binding
GO:0043123 IDA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050728 ISS negative regulation of inflammatory response
GO:0051260 IEA protein homooligomerization
GO:0071797 IEA:IDA LUBAC complex
GO:0097039 IDA protein linear polyubiquitination
GO:2000348 IDA regulation of CD40 signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000023211 Sharpin-001 protein_coding Mus_musculus 0 647
ENSMUST00000154477 Sharpin-004 retained_intron Mus_musculus 0 448
ENSMUST00000144816 Sharpin-003 retained_intron Mus_musculus 0 196
ENSMUST00000159429 Sharpin-008 protein_coding Mus_musculus 2.8026e-45 187
ENSMUST00000147001 Sharpin-009 retained_intron Mus_musculus 1.99965e-42 178
ENSMUST00000123112 Sharpin-002 retained_intron Mus_musculus 1.99965e-42 178

Loading