C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000223095 SERPINE1-001 ENSG00000106366 9606 + 7:101127089-101139266 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000223095
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000223095 15.592±0.00 6.027±0.00 1.049±0.00 1.116±0.65 3.692±1.25 14.349±13.58 2.568±2.38 7.483±4.63 4.024±1.16 123.285±120.09 1.562±0.75 30.819±33.69 556.261±245.26 6.289±5.26

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001300 IEP chronological cell aging
GO:0001525 IEP angiogenesis
GO:0002020 IPI protease binding
GO:0002576 TAS platelet degranulation
GO:0004867 IDA serine-type endopeptidase inhibitor activity
GO:0005102 IPI receptor binding
GO:0005515 IPI protein binding
GO:0005576 IDA extracellular region
GO:0005615 IDA extracellular space
GO:0005886 TAS plasma membrane
GO:0006351 TAS transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007596 TAS blood coagulation
GO:0010467 TAS gene expression
GO:0010469 IDA regulation of receptor activity
GO:0010757 IMP negative regulation of plasminogen activation
GO:0010951 IDA negative regulation of endopeptidase activity
GO:0014912 IDA negative regulation of smooth muscle cell migration
GO:0030168 TAS platelet activation
GO:0030194 IMP positive regulation of blood coagulation
GO:0030195 IC negative regulation of blood coagulation
GO:0030198 TAS extracellular matrix organization
GO:0030336 IDA negative regulation of cell migration
GO:0031012 IDA extracellular matrix
GO:0031093 TAS platelet alpha granule lumen
GO:0032757 IMP positive regulation of interleukin-8 production
GO:0033629 IDA negative regulation of cell adhesion mediated by integrin
GO:0035491 IMP positive regulation of leukotriene production involved in inflammatory response
GO:0042127 IEA regulation of cell proliferation
GO:0042730 TAS fibrinolysis
GO:0045765 IEA regulation of angiogenesis
GO:0045766 IMP positive regulation of angiogenesis
GO:0045944 TAS positive regulation of transcription from RNA polymerase II promoter
GO:0048260 IDA positive regulation of receptor-mediated endocytosis
GO:0050729 IGI positive regulation of inflammatory response
GO:0050829 IGI defense response to Gram-negative bacterium
GO:0051918 IDA negative regulation of fibrinolysis
GO:0061044 IGI negative regulation of vascular wound healing
GO:0061045 IC negative regulation of wound healing
GO:0070062 IDA extracellular vesicular exosome
GO:0071222 IMP cellular response to lipopolysaccharide
GO:0090026 IMP positive regulation of monocyte chemotaxis
GO:1902042 IMP negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000098 IDA negative regulation of smooth muscle cell-matrix adhesion
GO:2000352 IMP negative regulation of endothelial cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000077523 Serpine1-202 protein_coding Mus_musculus 0 1048
ENSMUST00000041388 Serpine1-201 protein_coding Mus_musculus 0 1048

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