C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: mitogen-activated protein kinase kinase 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000046963 Map2k4-005 ENSMUSG00000033352 10090 - 11:65688243-65788297 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000046963
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000046963 5.162±1.07 6.364±3.08 14.265±2.92 17.785±5.68 3.818±2.35 2.768±0.55 4.403±0.28 4.474±0.59 8.233±4.33 6.777±1.89 15.505±1.93 9.245±4.61 15.491±5.48 1.089±0.26

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007YN CIL_0007YN_0002 VISTA 11:65135465-65736246
CIL_0008WK CIL_0008WK_0002 VISTA 11:65348906-65951643

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000165 IPI MAPK cascade
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004708 IEA MAP kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005829 TAS cytosol
GO:0006915 IEA apoptotic process
GO:0007254 ISO JNK cascade
GO:0007257 ISO activation of JUN kinase activity
GO:0008545 IEA JUN kinase kinase activity
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030424 IEA axon
GO:0031435 IEA mitogen-activated protein kinase kinase kinase binding
GO:0032839 IEA dendrite cytoplasm
GO:0043065 IEA positive regulation of apoptotic process
GO:0043204 IEA perikaryon
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0045740 IEA positive regulation of DNA replication
GO:0051770 IEA positive regulation of nitric-oxide synthase biosynthetic process
GO:0061049 IEA cell growth involved in cardiac muscle cell development
GO:0071260 IEA cellular response to mechanical stimulus
GO:0072709 IEA cellular response to sorbitol

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000130761 map2k4a-001 protein_coding Danio_rerio 0 713
ENSDART00000093037 map2k4a-003 protein_coding Danio_rerio 0 713
ENSDART00000058834 map2k4a-002 protein_coding Danio_rerio 0 617
ENST00000353533 MAP2K4-001 protein_coding Homo_sapiens 0 2856
ENST00000415385 MAP2K4-002 protein_coding Homo_sapiens 0 2662
ENST00000438453 MAP2K4P1-001 transcribed_processed_pseudogene Homo_sapiens 0 1589
ENST00000536413 MAP2K4-005 retained_intron Homo_sapiens 0 1517
ENST00000538465 MAP2K4-008 nonsense_mediated_decay Homo_sapiens 0 813
ENST00000579089 MAP2K4-009 processed_transcript Homo_sapiens 0 771
ENST00000581941 MAP2K4-003 processed_transcript Homo_sapiens 0 1040
ENST00000582183 MAP2K4-010 nonsense_mediated_decay Homo_sapiens 0 621
ENST00000582377 MAP2K4-004 retained_intron Homo_sapiens 0 435
ENST00000582897 MAP2K4-006 processed_transcript Homo_sapiens 0 671
ENST00000585076 MAP2K4-007 retained_intron Homo_sapiens 0 562
ENST00000602305 MAP2K4-013 nonsense_mediated_decay Homo_sapiens 0 1338
ENST00000602375 MAP2K4-012 nonsense_mediated_decay Homo_sapiens 0 1338
ENST00000602537 MAP2K4-015 nonsense_mediated_decay Homo_sapiens 0 1127
ENST00000602584 MAP2K4P1-002 processed_transcript Homo_sapiens 0 2344
ENST00000602686 MAP2K4-014 nonsense_mediated_decay Homo_sapiens 0 920
ENST00000602811 MAP2K4-011 nonsense_mediated_decay Homo_sapiens 0 1655

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