C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: argonaute RISC catalytic subunit 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000044113 Ago2-001 ENSMUSG00000036698 10090 - 15:73095844-73184840 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000044113
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000044113 8.393±2.99 9.364±0.93 4.870±2.21 6.775±2.52 7.301±4.53 10.983±3.14 5.623±0.14 7.320±0.36 6.387±3.66 9.459±1.47 6.544±0.39 7.968±3.37 7.686±3.75 3.581±0.07

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002Y5 CIL_0002Y5_0002 CGP 15:72589621-73097554
CIL_0002XO CIL_0002XO_0002 CGP 15:73090392-73184840
CIL_0002XD CIL_0002XD_0002 CGP 15:73095844-73423191

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000340 ISS RNA 7-methylguanosine cap binding
GO:0000932 IDA cytoplasmic mRNA processing body
GO:0003723 IDA RNA binding
GO:0003729 IDA mRNA binding
GO:0004521 IDA endoribonuclease activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 ISO cytoplasm
GO:0005829 IDA cytosol
GO:0005844 ISS polysome
GO:0005845 ISS mRNA cap binding complex
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006379 IMP mRNA cleavage
GO:0009791 IMP post-embryonic development
GO:0010586 IDA miRNA metabolic process
GO:0010628 IMP positive regulation of gene expression
GO:0016020 IEA membrane
GO:0016442 ISS RISC complex
GO:0030154 IEA cell differentiation
GO:0030529 ISS ribonucleoprotein complex
GO:0031047 IMP gene silencing by RNA
GO:0031054 ISS pre-miRNA processing
GO:0035068 ISS micro-ribonucleoprotein complex
GO:0035197 ISS siRNA binding
GO:0035198 IMP miRNA binding
GO:0035278 ISS negative regulation of translation involved in gene silencing by miRNA
GO:0035279 ISS mRNA cleavage involved in gene silencing by miRNA
GO:0044822 IEA poly(A) RNA binding
GO:0045947 ISS negative regulation of translational initiation
GO:0046872 IEA metal ion binding
GO:0060213 IMP positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0070551 ISS endoribonuclease activity, cleaving siRNA-paired mRNA
GO:0090502 IEA RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900153 IMP positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000087187 CU929240.1-201 protein_coding Danio_rerio 0 1903
ENSDART00000156255 AGO1-001 protein_coding Danio_rerio 0 1352
ENSDART00000138318 AGO1-201 protein_coding Danio_rerio 0 1282
ENSDART00000129463 ago4-201 protein_coding Danio_rerio 0 399
ENST00000220592 AGO2-001 protein_coding Homo_sapiens 0 3884
ENST00000517293 AGO2-005 processed_transcript Homo_sapiens 0 433
ENST00000518019 AGO2-004 processed_transcript Homo_sapiens 0.00000000002 73
ENST00000519980 AGO2-002 protein_coding Homo_sapiens 0 2891
ENST00000520412 AGO2-008 retained_intron Homo_sapiens 0 630
ENST00000520628 AGO2-010 processed_transcript Homo_sapiens 0 355
ENST00000521325 AGO2-007 retained_intron Homo_sapiens 0 272
ENST00000523609 AGO2-003 nonsense_mediated_decay Homo_sapiens 0 3591
ENST00000524328 AGO2-006 protein_coding Homo_sapiens 0 255

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