C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein kinase C, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000050965 Prkca 10090 - 11:107933387-108343928 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000059595 Prkca-001 107933387-108343928 protein_coding
  ENSMUST00000100302 Prkca-004 107938177-107979639 protein_coding
  ENSMUST00000134725 Prkca-002 108191858-108343648 processed_transcript
  ENSMUST00000134910 Prkca-003 107978341-108012805 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLungMuscleOvaryPlacentaENSMUST00000059595ENSMUST00000100302ENSMUST00000134725ENSMUST00000134910
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta
ENSMUST00000059595 2.133±0.56 0.854±0.17 8.119±0.56 6.482±3.71 2.960±0.40 8.030±0.61 1.874±0.19 1.978±0.16 4.420±0.42 2.490±0.50 2.051±0.42 0.858±0.23
ENSMUST00000100302 N/A N/A N/A N/A N/A N/A 2.930±0.44 N/A N/A N/A 1.554±0.00 1.095±0.56
ENSMUST00000134725 7.559±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000134910 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.632±2.72 9.450±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000188 IMP inactivation of MAPK activity
GO:0001750 IDA photoreceptor outer segment
GO:0001933 IMP negative regulation of protein phosphorylation
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0001938 IEA positive regulation of endothelial cell proliferation
GO:0002026 IMP regulation of the force of heart contraction
GO:0002062 IDA chondrocyte differentiation
GO:0002159 IEA desmosome assembly
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004697 IDA protein kinase C activity
GO:0004698 IDA calcium-dependent protein kinase C activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005783 IEA endoplasmic reticulum
GO:0005829 IEA cytosol
GO:0005886 IDA plasma membrane
GO:0006468 IDA protein phosphorylation
GO:0006469 IMP negative regulation of protein kinase activity
GO:0006874 IMP cellular calcium ion homeostasis
GO:0006937 IMP regulation of muscle contraction
GO:0008270 IEA zinc ion binding
GO:0008285 IGI negative regulation of cell proliferation
GO:0010595 IEA positive regulation of endothelial cell migration
GO:0019899 IEA enzyme binding
GO:0030335 IEA positive regulation of cell migration
GO:0030425 IDA dendrite
GO:0030593 IMP neutrophil chemotaxis
GO:0031666 IEA positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0034351 IEA negative regulation of glial cell apoptotic process
GO:0035403 IEA histone kinase activity (H3-T6 specific)
GO:0035408 IEA histone H3-T6 phosphorylation
GO:0036289 IDA peptidyl-serine autophosphorylation
GO:0043025 IDA neuronal cell body
GO:0043536 IEA positive regulation of blood vessel endothelial cell migration
GO:0045177 IDA apical part of cell
GO:0045766 IEA positive regulation of angiogenesis
GO:0045785 IEA positive regulation of cell adhesion
GO:0045931 IEA positive regulation of mitotic cell cycle
GO:0046325 IMP negative regulation of glucose import
GO:0046627 IMP negative regulation of insulin receptor signaling pathway
GO:0050729 IMP positive regulation of inflammatory response
GO:0050730 IMP regulation of peptidyl-tyrosine phosphorylation
GO:0050930 IMP induction of positive chemotaxis
GO:0070062 IEA extracellular vesicular exosome
GO:0070555 IEA response to interleukin-1
GO:0071322 IDA cellular response to carbohydrate stimulus
GO:0090330 IEA regulation of platelet aggregation
GO:0097193 IMP intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000039241 prkca protein kinase C, alpha protein_coding Danio_rerio
ENSDARG00000086250 PRKCA (2 of 3) protein kinase C, alpha protein_coding Danio_rerio
ENSDARG00000087422 PRKCA (3 of 3) protein kinase C, alpha protein_coding Danio_rerio
ENSG00000154229 PRKCA protein kinase C, alpha protein_coding Homo_sapiens

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