C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serine (or cysteine) peptidase inhibitor, clade E, member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000037411 Serpine1 10090 - 5:137061504-137072272 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000041388 Serpine1-201 137061504-137072272 protein_coding
  ENSMUST00000077523 Serpine1-202 137061512-137072254 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000041388ENSMUST00000077523
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000041388 1.682±0.89 0.371±0.27 2.097±0.09 0.345±0.22 0.656±0.18 1.433±0.83 4.045±0.82 0.214±0.12 1.708±3.16 4.327±1.41 0.911±0.53 1.154±0.76 119.863±47.13 0.186±0.09
ENSMUST00000077523 5.718±2.99 0.891±0.30 1.236±0.64 0.379±0.10 0.793±0.25 0.514±0.22 7.605±2.29 0.628±0.27 1.849±3.16 7.413±1.90 0.512±0.47 3.145±1.63 118.326±70.38 0.238±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005LE CIL_0005LE_0002 CGP 5:137034993-137072272

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001300 IEA chronological cell aging
GO:0001525 IEA angiogenesis
GO:0002020 IEA protease binding
GO:0004867 IDA serine-type endopeptidase inhibitor activity
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005576 IEA extracellular region
GO:0005615 IBA extracellular space
GO:0010469 IEA regulation of receptor activity
GO:0010757 IEA negative regulation of plasminogen activation
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0014912 IEA negative regulation of smooth muscle cell migration
GO:0030194 IEA positive regulation of blood coagulation
GO:0030336 IEA negative regulation of cell migration
GO:0031012 IEA extracellular matrix
GO:0032757 IEA positive regulation of interleukin-8 production
GO:0033629 IEA negative regulation of cell adhesion mediated by integrin
GO:0035491 IEA positive regulation of leukotriene production involved in inflammatory response
GO:0042127 IGI regulation of cell proliferation
GO:0045765 IDA regulation of angiogenesis
GO:0045766 IEA positive regulation of angiogenesis
GO:0048260 IEA positive regulation of receptor-mediated endocytosis
GO:0050729 IEA positive regulation of inflammatory response
GO:0050829 IEA defense response to Gram-negative bacterium
GO:0051918 IEA negative regulation of fibrinolysis
GO:0061044 IEA negative regulation of vascular wound healing
GO:0070062 IEA extracellular vesicular exosome
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0090026 IEA positive regulation of monocyte chemotaxis
GO:1902042 IEA negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000098 IEA negative regulation of smooth muscle cell-matrix adhesion
GO:2000352 IEA negative regulation of endothelial cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056795 serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 protein_coding Danio_rerio
ENSG00000106366 SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 protein_coding Homo_sapiens

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