C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: protein kinase, AMP-activated, alpha 1 catalytic subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000132356 PRKAA1 9606 - 5:40759379-40798374 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000296800 PRKAA1-003 40768385-40798174 protein_coding
  ENST00000354209 PRKAA1-001 40762770-40798374 protein_coding
  ENST00000397006 PRKAA1-009 40777160-40798170 retained_intron
  ENST00000397128 PRKAA1-002 40759379-40798198 protein_coding
  ENST00000505783 PRKAA1-006 40764770-40771855 retained_intron
  ENST00000506652 PRKAA1-005 40764937-40798148 retained_intron
  ENST00000509874 PRKAA1-004 40767507-40798189 retained_intron
  ENST00000511248 PRKAA1-010 40777016-40798159 retained_intron
  ENST00000513152 PRKAA1-007 40764242-40764788 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000354209ENST00000397128ENST00000505783
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000354209 N/A N/A 5.157±0.00 6.061±0.00 19.621±0.00 22.291±0.00 2.343±0.00 16.414±0.00 10.203±0.00 8.658±0.00 5.200±0.00 21.543±0.00 N/A 17.820±3.51
ENST00000397128 13.353±0.00 9.653±0.00 8.976±0.00 5.505±0.06 8.528±0.00 1.187±0.00 4.716±0.91 10.442±1.52 9.180±0.38 13.016±2.82 2.475±0.85 9.600±2.85 3.493±0.28 5.429±2.28
ENST00000505783 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.377±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0001666 NAS response to hypoxia
GO:0003682 ISS chromatin binding
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004679 IEA AMP-activated protein kinase activity
GO:0004691 NAS cAMP-dependent protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005622 IC intracellular
GO:0005634 ISS nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006006 IEA glucose metabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0006633 IEA fatty acid biosynthetic process
GO:0006695 IEA cholesterol biosynthetic process
GO:0006914 IEA autophagy
GO:0007050 TAS cell cycle arrest
GO:0007165 TAS signal transduction
GO:0008022 IEA protein C-terminus binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008610 ISS lipid biosynthetic process
GO:0009411 IEA response to UV
GO:0009631 IEA cold acclimation
GO:0010332 ISS response to gamma radiation
GO:0010508 ISS positive regulation of autophagy
GO:0010628 IDA positive regulation of gene expression
GO:0014823 IEA response to activity
GO:0016055 IEA Wnt signaling pathway
GO:0016324 IEA apical plasma membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019395 IEA fatty acid oxidation
GO:0019900 IEA kinase binding
GO:0031000 IEA response to caffeine
GO:0031588 IEA AMP-activated protein kinase complex
GO:0031669 ISS cellular response to nutrient levels
GO:0032007 ISS negative regulation of TOR signaling
GO:0035174 ISS histone serine kinase activity
GO:0035404 IEA histone-serine phosphorylation
GO:0042149 ISS cellular response to glucose starvation
GO:0042542 IEA response to hydrogen peroxide
GO:0042593 ISS glucose homeostasis
GO:0042752 ISS regulation of circadian rhythm
GO:0043066 ISS negative regulation of apoptotic process
GO:0043234 IEA protein complex
GO:0045542 NAS positive regulation of cholesterol biosynthetic process
GO:0045821 ISS positive regulation of glycolytic process
GO:0046318 NAS negative regulation of glucosylceramide biosynthetic process
GO:0046872 IEA metal ion binding
GO:0047322 IEA [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0048511 IEA rhythmic process
GO:0050321 IEA tau-protein kinase activity
GO:0050405 IEA [acetyl-CoA carboxylase] kinase activity
GO:0050995 ISS negative regulation of lipid catabolic process
GO:0051291 IEA protein heterooligomerization
GO:0055089 ISS fatty acid homeostasis
GO:0060627 IEA regulation of vesicle-mediated transport
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0071361 IEA cellular response to ethanol
GO:0071417 IEA cellular response to organonitrogen compound
GO:0071456 IEA cellular response to hypoxia
GO:1901563 IEA response to camptothecin
GO:2000505 ISS regulation of energy homeostasis
GO:2001274 IEA negative regulation of glucose import in response to insulin stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060596 prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit protein_coding Danio_rerio
ENSMUSG00000050697 Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit protein_coding Mus_musculus

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