C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interferon regulatory factor 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000126456 IRF3 9606 - 19:49659569-49665875 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000309877 IRF3-006 49659572-49665169 protein_coding
  ENST00000377135 IRF3-201 49659570-49665875 protein_coding
  ENST00000377139 IRF3-001 49659572-49665875 protein_coding
  ENST00000442265 IRF3-202 49662539-49664838 protein_coding
  ENST00000593337 IRF3-027 49662301-49665835 protein_coding
  ENST00000593818 IRF3-022 49662175-49665847 protein_coding
  ENST00000593922 IRF3-011 49659579-49665705 protein_coding
  ENST00000594387 IRF3-013 49662427-49665780 retained_intron
  ENST00000595034 IRF3-023 49662133-49665788 protein_coding
  ENST00000595240 IRF3-016 49662375-49664523 retained_intron
  ENST00000596644 IRF3-015 49659575-49661003 retained_intron
  ENST00000596756 IRF3-025 49659758-49665613 protein_coding
  ENST00000596765 IRF3-008 49659579-49665705 protein_coding
  ENST00000596788 IRF3-026 49662585-49664723 nonsense_mediated_decay
  ENST00000596822 IRF3-017 49659572-49665755 protein_coding
  ENST00000597180 IRF3-029 49663421-49665754 processed_transcript
  ENST00000597198 IRF3-004 49659573-49665857 protein_coding
  ENST00000597369 IRF3-014 49663236-49663869 retained_intron
  ENST00000597636 IRF3-003 49659575-49665857 nonsense_mediated_decay
  ENST00000598108 IRF3-028 49662069-49665779 protein_coding
  ENST00000598808 IRF3-010 49659632-49665842 protein_coding
  ENST00000599144 IRF3-009 49659579-49665731 protein_coding
  ENST00000599223 IRF3-005 49659579-49665705 protein_coding
  ENST00000599680 IRF3-021 49659569-49661524 processed_transcript
  ENST00000600022 IRF3-012 49659579-49665705 protein_coding
  ENST00000600453 IRF3-020 49663373-49665843 protein_coding
  ENST00000600911 IRF3-007 49659572-49665231 protein_coding
  ENST00000601291 IRF3-002 49659572-49665802 protein_coding
  ENST00000601373 IRF3-024 49662239-49665784 protein_coding
  ENST00000601809 IRF3-019 49662454-49665859 protein_coding
  ENST00000602190 IRF3-018 49661595-49662329 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000309877ENST00000377139ENST00000593922ENST00000595240ENST00000597369ENST00000597636ENST00000598108ENST00000598808ENST00000599144ENST00000599223ENST00000599680ENST00000600911ENST00000601291ENST00000602190
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000309877 7.279±0.00 21.929±0.00 2.857±2.40 7.998±0.00 4.116±3.29 3.087±0.00 6.088±5.59 2.698±0.00 12.915±12.20 1.287±0.00 17.384±5.90 N/A 12.896±0.00
ENST00000377139 N/A N/A 0.358±0.00 1.317±0.00 N/A N/A N/A 0.307±0.00 N/A N/A 17.205±0.00 7.812±0.95 N/A
ENST00000593922 N/A N/A 10.535±0.00 5.486±0.00 14.277±0.00 3.702±0.00 N/A 3.420±0.00 14.604±0.00 N/A N/A N/A 21.465±0.00
ENST00000595240 N/A N/A 1.028±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000597369 N/A N/A N/A N/A 1.586±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000597636 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.096±0.00 4.623±0.00 N/A N/A
ENST00000598108 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.632±0.00 N/A N/A
ENST00000598808 N/A N/A N/A N/A N/A N/A N/A N/A 0.461±0.00 N/A N/A 8.859±0.12 N/A
ENST00000599144 N/A N/A N/A 6.630±0.00 N/A N/A 13.193±0.00 N/A N/A 3.456±0.00 19.515±1.31 25.452±4.98 14.039±0.00
ENST00000599223 N/A N/A N/A N/A N/A N/A N/A 5.813±0.00 N/A 2.683±0.00 N/A N/A N/A
ENST00000599680 N/A N/A N/A N/A N/A 0.299±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000600911 N/A N/A N/A N/A N/A 0.213±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000601291 6.229±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.359±0.00 9.276±6.74 12.926±4.95 N/A
ENST00000602190 N/A N/A 2.242±0.00 9.054±0.00 1.826±0.00 N/A 2.932±0.00 N/A 2.073±0.00 N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000975 IEA regulatory region DNA binding
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0003677 NAS DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003712 TAS transcription cofactor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0006915 TAS apoptotic process
GO:0006974 TAS cellular response to DNA damage stimulus
GO:0009617 IEA response to bacterium
GO:0016032 IEA viral process
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0031663 IEA lipopolysaccharide-mediated signaling pathway
GO:0032480 TAS negative regulation of type I interferon production
GO:0032481 TAS positive regulation of type I interferon production
GO:0032496 IEA response to lipopolysaccharide
GO:0032727 ISS positive regulation of interferon-alpha production
GO:0032728 ISS positive regulation of interferon-beta production
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0039530 TAS MDA-5 signaling pathway
GO:0042802 IPI identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 IEA response to exogenous dsRNA
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045087 TAS innate immune response
GO:0045351 IEA type I interferon biosynthetic process
GO:0045358 IEA negative regulation of interferon-beta biosynthetic process
GO:0050689 IEA negative regulation of defense response to virus by host
GO:0050715 IEA positive regulation of cytokine secretion
GO:0051607 ISS defense response to virus
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060337 TAS type I interferon signaling pathway
GO:0060340 IEA positive regulation of type I interferon-mediated signaling pathway
GO:0071359 IEA cellular response to dsRNA
GO:0071888 TAS macrophage apoptotic process
GO:0097300 IEA programmed necrotic cell death

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076251 irf3 interferon regulatory factor 3 protein_coding Danio_rerio
ENSMUSG00000003184 Irf3 interferon regulatory factor 3 protein_coding Mus_musculus

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